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A lysosomal surveillance response to stress extends healthspan

26 Jun 2025

Abstract excerpt

Abstract Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacuolar H+-ATPase subunits (for example, vha-6), which are essential for intestinal lumen acidification in Caenorhabditis...

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Share to Autophagy in Disease and Therapy
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PMID: 40571723
DOI: 10.1038/s41556-025-01693-y

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