Article

A VHL-1;HIF-1/SQRD1/COL-88 axis links extracellular matrix formation with longevity in <i>Caenorhabditis elegans</i>

2024-02-24

Abstract excerpt

The extracellular matrix (ECM) is a pivotal three-dimensional network crucial for tissue organization, cellular communication, and fundamental cellular processes, where collagens are the major chemical entity in amount. ECM deregulation is directly involved with several pathologies, such as tumour growth and invasiveness, atherosclerosis, and diabetic nephropathy. Mutations in the von Hippel-Lindau tumour suppress...

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Literature Corpus work: 04bc5480-3f44-5650-9985-7b7644f64828
DOI: 10.1101/2024.02.22.581513

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