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Article

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner.

Aging cell - 1 Aug 2013

Gharbi Hakam, Fabretti Francesca, Bharill Puneet, Rinschen Markus M, Brinkkötter Sibylle, Frommolt Peter, Burst Volker, Schermer Bernhard, Benzing Thomas, Müller Roman-Ulrich

Abstract excerpt

Signaling through the hypoxia-inducible factor hif-1 controls longevity, metabolism, and stress resistance in Caenorhabditis elegans. Hypoxia-inducible factor (HIF) protein levels are regulated through an evolutionarily conserved ubiquitin ligase complex. Mutations in the VHL gene, encoding a core component of this complex, cause a multitumor syndrome and renal cell carcinoma in humans. In the nematode,...

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Source

Identifiers

PMID: 23566034
DOI: 10.1111/acel.12081

Genes

FLCN
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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