Article

Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulation

2025-03-26

Abstract excerpt

The Notch signaling pathway is crucial for germline stem cell (GSC) regulation in C. elegans , yet the molecular and biological consequences of GLP-1/Notch mutations remain poorly understood. This study systematically analyzes commonly used and clinically relevant glp-1 loss- and gain-of-function mutations to investigate their effects on Notch activity at chromosomal, cellular, and tissue levels. Using complemen...

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Literature Corpus work: b96d5ef7-99f0-52cc-91e8-96a4b837e0ea
DOI: 10.1101/2025.03.25.645284

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