Article

A sensitized genetic screen to identify regulators of <i>C. elegans</i> germline stem cells

2021-10-05

Abstract excerpt

Germline stem cells (GSCs) in Caenorhabditis elegans are maintained by GLP-1/Notch signaling from the niche and by a downstream RNA regulatory network. Loss of the GLP-1 receptor causes GSCs to precociously undergo meiotic differentiation, the “Glp” phenotype, due to a failure to self-renew. lst-1 and sygl-1 are functionally redundant direct targets of GLP-1 signaling whose gene products work with PUF RNA bindi...

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Literature Corpus work: 30f58c80-b4ef-50b1-9357-94c603499254
DOI: 10.1101/2021.10.03.462952

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