Article

Loss of the distal-proximal GLP-1/Notch activation gradient in the aging C. elegans germline

2025-10-23

Abstract excerpt

In C. elegans hermaphrodites , the distal tip cells (DTCs) capping the distal gonad arms provide the niche signal, a Notch ligand, to maintain germline stem cell pools. Using fixed germlines, it was recently shown that the transcription of a Notch target gene decreased relatively early-on during adulthood. Here, we used the genetically encoded Notch Sensor Able to detect Lateral Signaling Activity (SALSA) to exam...

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Literature Corpus work: 543059bd-39ab-59bd-a1ae-5244ee91c7fb
DOI: 10.1101/2025.10.22.683991

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