Article

Reduction of Derlin activity suppresses Notch-dependent tumours in the <i>C. elegans</i> germ line

2021-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Regulating the balance between self-renewal (proliferation) and differentiation is key to the long-term functioning of all stem cell pools. In the Caenorhabditis elegans germline, the primary signal controlling this balance is the conserved Notch signaling pathway. Gain-of-function mutations in the GLP-1/Notch receptor cause increased stem cell self-renewal, resulting in a tumor of proliferatin...

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Literature Corpus work: 57a8e35d-cf8e-5b3e-ab3d-fb43f4a5082d
DOI: 10.1101/2021.07.02.450841

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