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Article

Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.

Genetics - 1 Jan 2003

Pepper Anita S-R, Killian Darrell J, Hubbard E Jane Albert

Abstract excerpt

glp-1 encodes a member of the highly conserved LIN-12/Notch family of receptors that mediates the mitosis/meiosis decision in the C. elegans germline. We have characterized three mutations that represent a new genetic and phenotypic class of glp-1 mutants, glp-1(Pro). The glp-1(Pro) mutants display gain-of-function germline pattern defects, most notably a proximal proliferation (Pro) phenotype. Each of three...

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Identifiers

PMID: 12586701
DOI: 10.1093/genetics/163.1.115
PMCID: PMC1462416

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Source receipt: pubmed, retrieved 7 Sept 2026.

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