Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PUF-8, a Pumilio homolog, inhibits the proliferative fate in the Caenorhabditis elegans germline.

G3 (Bethesda, Md.) - 1 Oct 2012

Racher Hilary, Hansen Dave

Abstract excerpt

Stem cell populations are maintained by keeping a balance between self-renewal (proliferation) and differentiation of dividing stem cells. Within the Caenorhabditis elegans germline, the key regulator maintaining this balance is the canonical Notch signaling pathway, with GLP-1/Notch activity promoting the proliferative fate. We identified the Pumilio homolog, PUF-8, as an inhibitor of the proliferative fate of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mitosis
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germ Cells

Share to Membrane Glycoproteins

Share to Receptors, Notch

Share to RNA-Binding Proteins

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 23050230
DOI: 10.1534/g3.112.003350
PMCID: PMC3464112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PUF-8, a Pumilio homolog, inhibits the proliferative fate in the Caenorhabditis elegans germline.PMID 23050230Read ↗

Regulation of the mitosis/meiosis decision in the <i>Caenorhabditis elegans</i> germlineSemantic proximity Read ↗

A sensitized genetic screen to identify regulators of <i>C. elegans</i> germline stem cellsSemantic proximity Read ↗

A PUF Hub Drives Self-Renewal in Caenorhabditis elegans Germline Stem Cells.Semantic proximity Read ↗

A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans.Semantic proximity Read ↗

Germline proliferation and its controlSemantic proximity Read ↗

Analysis of Germline Stem Cell Differentiation Following Loss of GLP-1 Notch Activity in Caenorhabditis elegansSemantic proximity Read ↗

C. elegans germline stem cells and their nicheSemantic proximity Read ↗

HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans.Semantic proximity Read ↗

A mutation in teg-4, which encodes a protein homologous to the SAP130 pre-mRNA splicing factor, disrupts the balance between proliferation and differentiation in the C. elegans germ line.Semantic proximity Read ↗

Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegansSemantic proximity Read ↗

DIV-1/PolA2 Promotes GLP-1/Notch-Mediated Cellular Events in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.