Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulation.

Biology open - 15 Feb 2026

John Nimmy S, Urman Michelle A, Mehmood Mahasin G, Gentile Vanessa, Lee ChangHwan

Abstract excerpt

The Notch signaling pathway is crucial for germline stem cell (GSC) regulation in Caenorhabditis elegans, yet the molecular and biological consequences of GLP-1/Notch mutations remain poorly understood. This study systematically analyzes commonly used and pathological glp-1 loss- (lf) and gain-of-function (gf) mutations to investigate their effects on Notch activity at nascent transcript (ATS), mRNA, and germline...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germ Cells

Share to Glucagon-Like Peptide 1

Share to Mutation

Share to Receptors, Notch

Share to Signal Transduction

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 41537259
DOI: 10.1242/bio.062008
PMCID: PMC12937919

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulation.PMID 41537259Read ↗

Genetic mutations in GLP-1/Notch pathway reveal distinct mechanisms of Notch signaling in germline stem cell regulationSemantic proximity Read ↗

GLP-1 Notch - LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets <i>lst-1</i> and <i>sygl-1</i>Semantic proximity Read ↗

A sensitized genetic screen to identify regulators of <i>C. elegans</i> germline stem cellsSemantic proximity Read ↗

Loss of the distal-proximal GLP-1/Notch activation gradient in the aging C. elegans germlineSemantic proximity Read ↗

Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegansSemantic proximity Read ↗

A somatic proteoglycan controls Notch-directed germ cell fateSemantic proximity Read ↗

A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Reduction of Derlin activity suppresses Notch-dependent tumours in the <i>C. elegans</i> germ lineSemantic proximity Read ↗

Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors.Semantic proximity Read ↗

Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development.Semantic proximity Read ↗

PUF-8, a Pumilio homolog, inhibits the proliferative fate in the Caenorhabditis elegans germline.Semantic proximity Read ↗

Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.