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A somatic proteoglycan controls Notch-directed germ cell fate

18 Nov 2021

Abstract excerpt

Communication between the soma and germline optimizes germ cell fate programs. Notch receptors are key determinants of germ cell fate but how somatic signals direct Notch-dependent germ cell behavior is undefined. Here we demonstrate that SDN-1 (syndecan-1), a somatic transmembrane proteoglycan, controls expression of the GLP-1 (germline proliferation-1) Notch receptor in the Caenorhabditis elegans germline. We...

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PMID: 34795288
DOI: 10.1038/s41467-021-27039-4

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