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Article

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

13 Apr 2022

Abstract excerpt

BACKGROUND: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents (LRAs) have been reported to present variable ex vivo potencies. Here, we investigated the molecular mechanisms underlying the potency variability of one LRA: the DNA...

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PMID: 35429693
DOI: 10.1016/j.ebiom.2022.103985

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