Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

Abstract excerpt

Among CD4+ T-cells, T helper 17 (Th17) cells are particularly susceptible to HIV-1 infection and are depleted from mucosal sites, which causes damage to the gut barrier resulting in microbial translocation-induced systemic inflammation, a hallmark of disease progression. Furthermore, a proportion of latently infected Th17 cells persist long-term in the gastro-intestinal lymphatic tract, where low-level HIV-1 trans...

Topics

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• Autoimmunity
• Cytokine Signaling Pathways and Interactions
• Cytomegalovirus and herpesvirus research
• Dinoprostone
• Gene Knockdown Techniques
• HIV Research and Treatment
• Immune Cell Function and Interaction
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

c4521448-f127-5d0b-88b6-e232ac875f05

DOI

10.1101/2021.03.27.435072