Article

Novel Role of UHRF1 in DNA methylation-mediated repression of latent HIV-1

2021-06-15

Abstract excerpt

<h4>ABSTRACT</h4> The multiplicity, heterogeneity and dynamic nature of HIV-1 latency mechanisms are reflected in the current lack of functional cure for HIV-1 and in the various reported ex vivo potencies of latency- reversing agents. Here, we investigated the molecular mechanisms underlying the potency of the DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-AzadC) in HIV-1 latency reversal. Doing so, we unc...

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Literature Corpus work: 3fbecbd4-f3e3-5da5-a7d0-c49572fb3dad
DOI: 10.1101/2021.06.15.448539

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