Back to search

Article

Fusion Loop Modified and Mature Dengue Virus Elicits Protective Serum with Minimal Antibody Dependent Enhancement

2026-02-19

Abstract excerpt

<h4>ABSTRACT</h4> A balanced and safe vaccine against all four-dengue virus (DENV) serotypes is urgently needed. Although the currently licensed DENV vaccines demonstrate efficacy, they also raise concern about vaccine-associated disease enhancement, particularly in DENV-naïve individuals. The conserved, immunodominant fusion loop (FL) epitope is the target of cross-reactive, weakly neutralizing antibodies (Abs)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b955d9f2-e5a5-5630-aa95-67109bd97e35
DOI
10.64898/2026.02.18.706631
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Fusion Loop Modified and Mature Dengue Virus Elicits Protective Serum with Minimal Antibody Dependent EnhancementDOI 10.64898/2026.02.18.706631
Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion LoopSemantic proximity
Evolution of a functionally intact but antigenically distinct DENV fusion loopSemantic proximity
mRNA-LNP Vaccines Encoding for Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADESemantic proximity
A novel immunogen comprising a bc loop and mutant fusion loop epitopes generates potent neutralization and protective abilities against flaviviruses without risk of disease enhancementSemantic proximity
A dengue monovalent vaccine with novel structure provides cross-protection against four serotypes of dengue virusSemantic proximity
An epitope-resurfaced virus-like particle can induce broad neutralizing antibody against four serotypes of dengue virusSemantic proximity
An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with <i>in vivo</i> therapeutic potencySemantic proximity
Development of New Live-Attenuated Vaccine Candidates Lacking Antibody-Dependent Enhancement (ADE) Against DengueSemantic proximity
Generation of Mature DENVs via Genetic Modification and Directed EvolutionSemantic proximity
Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk.Semantic proximity
Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibodySemantic proximity
Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domainsSemantic proximity
Select a neighboring publication to make it the new centre.