Article

mRNA-LNP Vaccines Encoding for Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADE

2025-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Dengue virus (DENV) is the most common mosquito-borne virus in the world, causing nearly 400 million infections annually, with the number of cases predict to increase over time. Despite this prevalence there are no widely approved vaccine for DENV naïve individuals or therapeutics. DENV consists of four distinct serotypes, DENV 1-4, that share 60-70% homology. Development of a safe and efficacio...

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Literature Corpus work: 34b7aca3-88db-541e-86fb-725ba4a7550a
DOI: 10.1101/2025.07.21.665855

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