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An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with <i>in vivo</i> therapeutic potency

2020-10-04

Abstract excerpt

Dengue virus (DENV), from the genus flavivirus of the family flaviviridae , causes serious health problems globally. Human monoclonal antibodies (HuMAb) can be used to elucidate the mechanisms of neutralization and antibody-dependent enhancement (ADE) of DENV infections, leading to the development of a vaccine or therapeutic antibodies. Here, we generated eight HuMAb clones from an Indonesian patient infected wi...

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Literature Corpus work
898b8d4d-7ef4-51d0-a92a-79354a9b86e0
DOI
10.1101/2020.10.03.324731
Open publication

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