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Article

Generation of Mature DENVs via Genetic Modification and Directed Evolution

28 Apr 2022

Abstract excerpt

and are the target for vaccine development. Here, we used multiple strategies, including protein engineering and natural and directed evolution to generate DENV1, -2, -3, and -4 variants that are highly mature without compromising replication efficiency compared to the parental strains. Given the clinical importance of mature DENVs in immunity, this work provides a roadmap for engineering highly mature DENV that...

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PMID: 35481749
DOI: 10.1128/mbio.00386-22

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