Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of a functionally intact but antigenically distinct DENV fusion loop

12 Jul 2023

Abstract excerpt

A hallmark of dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. Antibody-dependent enhancement is linked to antibodies targeting the fusion loop (FL) motif of the envelope protein, which is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insect symbiosis and bacterial influences
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37725085
DOI: 10.7554/elife.87555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of a functionally intact but antigenically distinct DENV fusion loopPMID 37725085Read ↗

Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion LoopSemantic proximity Read ↗

Fusion Loop Modified and Mature Dengue Virus Elicits Protective Serum with Minimal Antibody Dependent EnhancementSemantic proximity Read ↗

An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with <i>in vivo</i> therapeutic potencySemantic proximity Read ↗

Mechanistic Study of Broadly Neutralizing Human Monoclonal Antibodies against Dengue Virus That Target the Fusion LoopSemantic proximity Read ↗

An epitope-resurfaced virus-like particle can induce broad neutralizing antibody against four serotypes of dengue virusSemantic proximity Read ↗

A dengue monovalent vaccine with novel structure provides cross-protection against four serotypes of dengue virusSemantic proximity Read ↗

Structure and Function Analysis of Therapeutic Monoclonal Antibodies against Dengue Virus Type 2Semantic proximity Read ↗

A novel immunogen comprising a bc loop and mutant fusion loop epitopes generates potent neutralization and protective abilities against flaviviruses without risk of disease enhancement.Semantic proximity Read ↗

IgG3 Hinge Architecture Expands Dengue Virus Breadth of A Quaternary Epitope Dependent Zika Virus Cross-Neutralizing AntibodySemantic proximity Read ↗

Distinct mechanisms of antibody-mediated HCV neutralization revealed by nanobody-guided epitope mappingSemantic proximity Read ↗

A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode.Semantic proximity Read ↗

Structure-guided affinity maturation of a single-chain variable fragment antibody against the Fu-bc epitope of the dengue virus envelope proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.