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Evolution of a functionally intact but antigenically distinct DENV fusion loop

12 Jul 2023

Abstract excerpt

A hallmark of dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. Antibody-dependent enhancement is linked to antibodies targeting the fusion loop (FL) motif of the envelope protein, which is...

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Insect symbiosis and bacterial influences
Mosquito-borne diseases and control
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37725085
DOI: 10.7554/elife.87555

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