Article

Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

2021-04-29

Abstract excerpt

Huntington’s disease is a fatal neurodegenerative disease characterized by striatal neurodegeneration, aggregation of mutant Huntingtin and the presence of reactive astrocytes. Astrocytes are important partners for neurons and engage in a specific reactive response in Huntington’s disease that involves morphological, molecular and functional changes. How reactive astrocytes contribute to Huntington’s disease is st...

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Literature Corpus work: b95148fb-fd92-5270-8161-00fa82f227cc
DOI: 10.1101/2021.04.29.441924

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