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Article

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.

Human molecular genetics - 1 Aug 2010

Faideau Mathilde, Kim Jinho, Cormier Kerry, Gilmore Richard, Welch Mackenzie, Auregan Gwennaelle, Dufour Noelle, Guillermier Martine, Brouillet Emmanuel, Hantraye Philippe, Déglon Nicole, Ferrante Robert J, Bonvento Gilles

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder previously thought to be of primary neuronal origin, despite ubiquitous expression of mutant huntingtin (mHtt). We tested the hypothesis that mHtt expressed in astrocytes may contribute to the pathogenesis of HD. To better understand the contribution of astrocytes in HD in vivo, we developed a novel mouse model using lentiviral vectors that results in...

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Identifiers

PMID: 20494921
DOI: 10.1093/hmg/ddq212
PMCID: PMC2901144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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