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Article

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states.

Genome research - 1 Jan 2022

Ziff Oliver J, Clarke Benjamin E, Taha Doaa M, Crerar Hamish, Luscombe Nicholas M, Patani Rickie

Abstract excerpt

Astrocytes contribute to motor neuron death in amyotrophic lateral sclerosis (ALS), but whether they adopt deleterious features consistent with inflammatory reactive states remains incompletely resolved. To identify inflammatory reactive features in ALS human induced pluripotent stem cell (hiPSC)-derived astrocytes, we examined transcriptomics, proteomics, and glutamate uptake in VCP-mutant astrocytes. We...

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Identifiers

PMID: 34963663
DOI: 10.1101/gr.275939.121
PMCID: PMC8744676

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