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Article

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.

Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2009

Bradford Jennifer, Shin Ji-Yeon, Roberts Meredith, Wang Chuan-En, Li Xiao-Jiang, Li Shihua

Abstract excerpt

Huntington disease (HD) is an inherited neurological disorder caused by a polyglutamine expansion in the protein huntingtin and is characterized by selective neurodegeneration that preferentially occurs in striatal medium spiny neurons. Because the medium spiny neurons are innervated abundantly by glutamatergic axons from cortical neurons, the preferential degeneration in the striatal neurons supports the...

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Identifiers

PMID: 20018729
DOI: 10.1073/pnas.0911503106
PMCID: PMC2799722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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