Article

Astrocytic Reactivity Triggered by defective Mitophagy Activates NF-kB Signaling and Causes Neurotoxicity in Frontotemporal Dementia Type 3

2021-03-16

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<title>Abstract</title> <bold>Background</bold>: Frontotemporal dementia type 3 (FTD3) caused by a point mutation in the charged multivesicular body protein 2B (CHMP2B), affects mitochondrial ultrastructure and function as well as endosomal-lysosomal fusion in neurons. However, there is a critical knowledge gap in understanding how mutations in CHMP2B affect astrocytes. Hence, we investigated the disease mecha...

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Literature Corpus work: abcd97ad-5162-590f-a076-16900474b906
DOI: 10.21203/rs.3.rs-310167/v1

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