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Article

Oligodendroglial Mutant Huntingtin Contributes to Neuroinflammation in Huntington's Disease Mice.

Neuroscience bulletin - 1 Jul 2026

Li Xinhui, Zhou Gongke, Xu Shuying, Yang Tianqi, Yin Shurui, Yang Sitong, Wu Yi, Zhou Xinqi, Yang Su, Tong Huichun, Li Xiao-Jiang, Li Shihua

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by poly-glutamine expansion in the mutant huntingtin (mHTT) protein. While the pathogenesis involves both cell-autonomous and non-cell-autonomous mechanisms, the role of specific intercellular crosstalk in HD remains unclear. The PLP-150Q mouse model, which expresses mHTT selectively in oligodendrocytes, serves as an excellent platform...

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Source

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Identifiers

PMID: 41495356
DOI: 10.1007/s12264-025-01565-3
PMCID: PMC13388632

Genes

CD68
GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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