Article

Striatal compartmentalization and clustering of different subtypes of astrocytes is altered in the zQ175 Huntington’s disease mouse model

2021-12-01

Abstract excerpt

Huntington’s disease (HD) is a devastating neurodegenerative disease that primarily affects the striatum, a brain region that controls movement and some forms of cognition. Dysfunction and loss of medium spiny neurons of the striatum is accompanied by astrogliosis (increased astrocyte density and pathology). For decades, astrocytes were considered a homogeneous cell type, but recent transcriptomic analyses reveale...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c61b3b18-df4a-5f43-a8d1-fc1547ecf241
DOI: 10.1101/2021.11.29.470488

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Striatal compartmentalization and clustering of different subtypes of astrocytes is altered in the zQ175 Huntington’s disease mouse modelDOI 10.1101/2021.11.29.470488Read

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice.Semantic proximity Read

Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in NeurodegenerationSemantic proximity Read

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease.Semantic proximity Read

Spatial and temporal diversity of astrocyte phenotypes in Spinocerebellar ataxia type 1 miceSemantic proximity Read

Varicose-projection astrocytes: a reactive phenotype associated with neuropathologySemantic proximity Read

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte stateSemantic proximity Read

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Semantic proximity Read

Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologiesSemantic proximity Read

Region-specific homeostatic identity of astrocytes is essential for defining their reactive phenotypes following pathological insultsSemantic proximity Read

Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathwaySemantic proximity Read

Molecular basis of astrocyte diversity and morphology across the CNS in health and diseaseSemantic proximity Read