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Article

Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Sept 2017

Hong Yan, Zhao Ting, Li Xiao-Jiang, Li Shihua

Abstract excerpt

In the brain, astrocytes secrete diverse substances that regulate neuronal function and viability. Exosomes, which are vesicles produced through the formation of multivesicular bodies and their subsequent fusion with the plasma membrane, are also released from astrocytes via exocytotic secretion. Astrocytic exosomes carry heat shock proteins that can reduce the cellular toxicity of misfolded proteins and prevent...

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Identifiers

PMID: 28893927
DOI: 10.1523/JNEUROSCI.1418-17.2017
PMCID: PMC5618269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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