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Article

SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes.

Brain : a journal of neurology - 29 Nov 2021

Birolini Giulia, Verlengia Gianluca, Talpo Francesca, Maniezzi Claudia, Zentilin Lorena, Giacca Mauro, Conforti Paola, Cordiglieri Chiara, Caccia Claudio, Leoni Valerio, Taroni Franco, Biella Gerardo, Simonato Michele, Cattaneo Elena, Valenza Marta

Abstract excerpt

Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its biosynthesis is severely reduced in mouse models of Huntington's disease. One possible mechanism is a diminished nuclear translocation of the transcription factor sterol regulatory element-binding protein 2 (SREBP2) and, consequently, reduced activation of SREBP2-controlled genes in the cholesterol biosynthesis pathway....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33974044
DOI: 10.1093/brain/awab186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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