Article

Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions

2025-01-12

Abstract excerpt

<h4>Aims</h4> Parkinson’s disease is considered biologically a neuronal α-synuclein disease, largely ignoring the more widespread α-synuclein deposition that occurs in astrocytes, with the aim of this study to identify whether astrocytes accumulate small α-synuclein aggregates before or after neurons. <h4>Methods</h4> Fixed serial midbrain and striatal sections from M83 A53T transgenic mouse model of Parkinson’s...

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Literature Corpus work: b9436e8a-8110-5bff-aeaa-d3c62b7000f5
DOI: 10.1101/2025.01.09.632283

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