Article

Proteostasis dysregulation in p.A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson’s disease model with Lewy-like pathology

2024-11-07

Abstract excerpt

Alpha-Synuclein (αSyn) plays a central role in Parkinson’s disease (PD) and the p.A53T mutation causes an early-onset familial form of PD with severe manifestations. The pathological effects of the p.A53T-αSyn mutation have been extensively investigated in neurons, yet the consequences on astrocytes and astrocytic contribution to PD pathology are understudied. Here, we differentiated induced pluripotent stem cells...

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Literature Corpus work: 812abde4-51d9-5a82-acb6-7059a3b3834a
DOI: 10.1101/2024.11.06.621638

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