Article
Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.
Molecular brain - 21 Apr 2010
Gu Xing-Long, Long Cai-Xia, Sun Lixin, Xie Chengsong, Lin Xian, Cai Huaibin
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is the most common movement disorder. While neuronal deposition of alpha-synuclein serves as a pathological hallmark of PD and Dementia with Lewy Bodies, alpha-synuclein-positive protein aggregates are also present in astrocytes. The pathological consequence of astrocytic accumulation of alpha-synuclein, however, is unclear. RESULTS: Here we show that PD-related A53T mutant...
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