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Article

Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy

19 Dec 2018

Abstract excerpt

Multiple system atrophy, characterized by atypical Parkinsonism, results from central nervous system (CNS) cell loss and dysfunction linked to aggregates of the normally pre-synaptic α-synuclein protein. Mostly cytoplasmic pathological α-synuclein inclusion bodies occur predominantly in oligodendrocytes in affected brain regions and there is evidence that α-synuclein released by neurons is taken up preferentially...

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PMID: 30572656
DOI: 10.3390/ijms19124129

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