Article

Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

2022-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB), and in oligodendrocytes in multiple system atrophy (MSA). Although the accumulation of aSyn in astrocytes has previously been described in PD, PDD and DLB, the biochemical properties of aSyn in thi...

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Literature Corpus work: 55890775-c76c-5b37-9092-ad371a4dd495
DOI: 10.1101/2022.05.29.493876

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