Article

Neuropathology in an α-synuclein preformed fibril mouse model occurs independent of the Parkinson’s disease-linked lysosomal ATP13A2 protein

2024-08-09

Abstract excerpt

Loss-of-function mutations in the ATP13A2 ( PARK9 ) gene are implicated in early-onset autosomal recessive Parkinson’s disease (PD) and other neurodegenerative disorders. ATP13A2 encodes a lysosomal transmembrane P 5B -type ATPase that is highly expressed in brain and specifically within the substantia nigra. Recent studies have revealed its normal role as a lysosomal polyamine transporter, although its contri...

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Literature Corpus work: fa44d932-6b56-564e-aba6-af8c7b5280e9
DOI: 10.1101/2024.08.07.607077

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