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Article

Generalized fear following acute stress is caused by change in co-transmitter identity of serotonergic neurons

2023-05-11

Abstract excerpt

Overgeneralization of fear to harmless situations is a core feature of anxiety disorders resulting from acute stress, yet the mechanisms by which fear becomes generalized are poorly understood. Here we show that generalized fear in mice in response to footshock results from a transmitter switch from glutamate to GABA in serotonergic neurons of the lateral wings of the dorsal raphe. We observe a similar change in t...

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Identifiers and source

Literature Corpus work
b9344e68-d981-53b9-ab30-245796a28900
DOI
10.1101/2023.05.10.540268
Open publication

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Generalized fear following acute stress is caused by change in co-transmitter identity of serotonergic neuronsDOI 10.1101/2023.05.10.540268
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