Article

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

2020-01-09

Abstract excerpt

<h4>Background</h4> Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, cancer cells are highly sensitive to ferroptosis, a form of regulated cell death that is caused by oxidative stress through excess levels of iron-dependent peroxidation of polyunsaturated fat...

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Literature Corpus work: b932e25d-2499-58de-b7a3-b7bcc4813cc9
DOI: 10.1101/2020.01.08.899609

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