Article

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity

2025-01-21

Abstract excerpt

<h4>Summary</h4> Triple-negative breast cancer (TNBC), defined by the lack of estrogen, progesterone, and HER2 receptor expressions, is aggressive and lacks targeted treatment options. Adenosine deaminase acting on RNA 1 (ADAR1) has been shown to contribute to TNBC tumorigenesis by modulating an innate immune response. However, little is known about its role in the regulation of metabolic fitness of TNBC. We test...

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Literature Corpus work: 12e63dc0-9fc7-59c3-be74-885ccd60fc17
DOI: 10.1101/2025.01.16.633410

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