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Article

Ferroptosis: the vulnerability within a cancer monster

15 May 2023

Abstract excerpt

Treatment-resistant cancer, such as neuroendocrine prostate cancer (NEPC), is a lethal disease with limited therapeutic options. RB1 is a tumor suppressor gene that is lost in a majority of NEPC tumors. In this issue of the JCI, Wang and colleagues examined how RB1 loss may sensitize cancer cells to ferroptosis inducers through elevation of ACSL4, a key enzyme that promotes lipid peroxidation and triggers...

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PMID: 37183818
DOI: 10.1172/jci170027

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