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Article

Phospholipase PAFAH2 Mediates Ferroptosis Surveillance and Lipid Remodeling to Promote Resistance in KEAP1 Mutant Cancers.

ACS chemical biology - 18 Jul 2025

Ruiz Stephen B, Tylawsky Daniel E, Shah Janki, Saoi Michelle, Cuevas Brandon, Desai Shanay, Racz Boglarka, Perea Ana Marie, Izawa-Ishiguro Arianna R, Cross Justin, Heller Daniel A

Abstract excerpt

Although ferroptosis resistance is prevalent among many cancer cell types, precisely how ferroptosis surveillance mechanisms are induced remains elusive due to the heterogeneity of the cellular mutational status and metabolic states. Here, we find that phospholipase PAFAH2 regulates ferroptosis through its unique ability to specifically detoxify membrane-bound oxidized phospholipids in KEAP1 mutant and...

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Topics

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Share to Cell Line, Tumor
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferroptosis

Share to KEAP1 gene

Share to Kelch-Like ECH-Associated Protein 1

Share to Lung Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 40600963
DOI: 10.1021/acschembio.5c00273
PMCID: PMC13411451

Genes

PAFAH2
KEAP1
GPX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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