Article

Unraveling a fine balance between ferroptosis, lipid metabolism, and hormonal protection in Leydig cell steroidogenesis

2026-07-06

Abstract excerpt

Leydig cells (LCs) are essential for male reproductive function due to their role in testosterone synthesis, a process critically dependent on mitochondrial cholesterol transport mediated by the Steroidogenic Acute Regulatory protein (StAR). Despite their importance, LCs are highly sensitive to metabolic and exogenous stressors. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidati...

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Literature Corpus work: 45a11cf5-c870-59ad-9c9c-47bd8e481ba1
DOI: 10.64898/2026.07.03.736405

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