Article

Tumor control of lysosomal acidification promotes lipoprotein assimilation and ferroptosis resistance

2026-08-26

Abstract excerpt

Lysosomes are acidic organelles that fuel cancer progression by facilitating nutrient acquisition and metabolic adaptation, yet the determinants through which cancer cells sustain specialized lysosomal functions are not fully delineated. Notably, assimilation of dietary antioxidants within lipoproteins, a lysosome-dependent process, protects tumors from ferroptosis, an oxidative form of cell death, raising the pos...

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Literature Corpus work: 1c1d632d-c27b-5a7f-a521-9c5701e6b8dc
DOI: 10.64898/2026.08.25.747075

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