Article

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator

2023-06-07

Abstract excerpt

The crosstalk between prostate cancer (PCa) cells and the tumor microenvironment plays a pivotal role in disease progression and metastasis and could provide novel opportunities for patient treatment. Macrophages are the most abundant immune cells in the prostate tumor microenvironment (TME) and are capable of killing tumor cells. To identify genes in the tumor cells that are critical for macrophage-mediated killi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92bd2ff0-7e74-56fd-b2e8-ad64d76e99b5
DOI: 10.1101/2023.06.06.543873

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulatorDOI 10.1101/2023.06.06.543873Read

An anti-androgen resistance-related gene signature acts as a prognostic marker and increases enzalutamide efficacy via PLK1 inhibition in prostate cancerSemantic proximity Read

Deciphering single-cell heterogeneity and cellular ecosystem dynamics during prostate cancer progressionSemantic proximity Read

Resolving the immune landscape of human prostate at a single-cell level in health and cancerSemantic proximity Read

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancerSemantic proximity Read

Overcome Prostate Cancer Resistance to Immune Checkpoint Therapy with Ketogenic Diet-Induced Epigenetic ReprogrammingSemantic proximity Read

Summary data-based mendelian randomization and single-cell RNA sequencing analyses identify key genes associated with ubiquitination in prostate cancerSemantic proximity Read

Integrated multi-omics analysis reveals the remodeling characteristics of the immune microenvironment in mCRPC and the key regulatory role of BRAFSemantic proximity Read

Identifying a Ferroptosis-Related Gene Signature for Predicting Biochemical Recurrence of Prostate CancerSemantic proximity Read

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancerSemantic proximity Read

Spatiotemporal profiling reveals the role of inflammatory niche in driving prostate cancerSemantic proximity Read

Single-cell proteomics defines the cellular heterogeneity of localized prostate cancerSemantic proximity Read

FOXA1 knock-out via CRISPR/Cas9 altered Casp-9, Bax, CCND1, CDK4, and fibronectin expressions in LNCaP cells.Semantic proximity Read