Article

Glucocorticoid receptor inhibition enables tumor-infiltrating macrophages to overcome immunotherapy resistance in advanced melanoma

2025-12-29

Abstract excerpt

<title>Abstract</title> <p>Immune-checkpoint inhibitors (ICIs) benefit patients with advanced melanoma, yet resistance remains common and the myeloid circuits that limit response are incompletely defined. We identify glucocorticoid receptor (GR) signaling in tumor-associated macrophages (TAMs) as a druggable brake on antitumor immunity under PD 1 blockade. Myeloid-specific GR deletion restored immune recognition...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8df0ff3-1f19-5f92-8afe-b455310bdc0a
DOI: 10.21203/rs.3.rs-8378434/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoid receptor inhibition enables tumor-infiltrating macrophages to overcome immunotherapy resistance in advanced melanomaDOI 10.21203/rs.3.rs-8378434/v1Read

Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axisSemantic proximity Read

An endogenous glucocorticoid-cytokine signaling circuit promotes CD8 <sup>+</sup> T cell dysfunction in the tumor microenvironmentSemantic proximity Read

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 ImmunotherapySemantic proximity Read

Glucocorticoid receptor activation reprograms NK cells to drive AREG-mediated immunosuppression in skin cancerSemantic proximity Read

Macrophage reprogramming—rather than depletion—is efficacious in a specific subset of colorectal tumor modelsSemantic proximity Read

Myeloid compartment reprogramming through nanoparticle-delivered resiquimod blocks paracrine growth support and activates phagocytosis to slow tumor progression in endogenous mouse medulloblastoma and diffuse midline glioma modelsSemantic proximity Read

Systemic effects of melanoma-secreted MIDKINE in the inhibition of dendritic cell differentiation and functionSemantic proximity Read

The c.1085A>G Genetic Variant of CSF1R Gene Regulates Tumor Immunity by Altering the Proliferation, Polarization, and Function of Macrophages.Semantic proximity Read

CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant MelanomaSemantic proximity Read

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity.Semantic proximity Read

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells.Semantic proximity Read

Adverse prognosis of GM-CSF expression in human cutaneous melanomaSemantic proximity Read