Article
Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity.
The Journal of experimental medicine - 5 Mar 2018
Hoves Sabine, Ooi Chia-Huey, Wolter Carsten, Sade Hadassah, Bissinger Stefan, Schmittnaegel Martina, Ast Oliver, Giusti Anna M, Wartha Katharina, Runza Valeria, Xu Wei, Kienast Yvonne, Cannarile Michael A, Levitsky Hyam, Romagnoli Solange, De Palma Michele, Rüttinger Dominik, Ries Carola H
Abstract excerpt
Depletion of immunosuppressive tumor-associated macrophages (TAMs) or reprogramming toward a proinflammatory activation state represent different strategies to therapeutically target this abundant myeloid population. In this study, we report that inhibition of colony-stimulating factor-1 receptor (CSF-1R) signaling sensitizes TAMs to profound and rapid reprogramming in the presence of a CD40 agonist before their...
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