Article

Macrophage reprogramming—rather than depletion—is efficacious in a specific subset of colorectal tumor models

2023-08-03

Abstract excerpt

<title>Abstract</title> <p>Despite the abundance of macrophages in colorectal cancer (CRC), macrophage-targeted therapy has not demonstrated significant clinical benefit. Here, we show that macrophage populations differ across the consensus molecular subtypes (CMS) of CRC and report the first preclinical study of macrophage targeting using mouse models stratified by CMS class. Whereas pan-macrophage ablation, usi...

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Literature Corpus work: 35c55d43-8b82-58d3-87f8-556329515d5f
DOI: 10.21203/rs.3.rs-3212822/v1

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