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Myeloid compartment reprogramming through nanoparticle-delivered resiquimod blocks paracrine growth support and activates phagocytosis to slow tumor progression in endogenous mouse medulloblastoma and diffuse midline glioma models

2026-04-09

Abstract excerpt

<h4>ABSTRACT</h4> In pediatric brain tumors medulloblastoma (MB) and diffuse midline glioma (DMG), tumor-associated myeloid cells (TAMs) support malignant progression by secreting paracrine growth factors and suppressing local immune function. We studied the potential for reversing this cancer-supportive phenotype by stimulating TAM pathogen receptors using ResiPOx, a brain-permeant, polyoxazoline nanoparticle fo...

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Literature Corpus work
9d889a1e-1ca6-5edb-9430-8b277a36d0cb
DOI
10.64898/2026.04.07.714454
Open publication

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