Article

CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant Melanoma

2023-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Approximately 50% of advanced melanomas harbor activating BRAF V600E mutations that are sensitive to BRAF inhibition. However, the duration of the response to BRAF inhibitors (BRAFi) has been limited due to the development of acquired resistance, which is preceded by recruitment of immunosuppressive myeloid cells and regulatory T cells (T regs ). While the addition of MAPK/ERK kinase 1 inhibit...

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Literature Corpus work: 90509304-e247-59cb-92aa-96306d436027
DOI: 10.1101/2023.08.01.551524

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