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Article

The c.1085A>G Genetic Variant of CSF1R Gene Regulates Tumor Immunity by Altering the Proliferation, Polarization, and Function of Macrophages.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2017

Yeh Yu-Min, Hsu Shan-Ju, Lin Peng-Chan, Hsu Keng-Fu, Wu Pei-Ying, Su Wu-Chou, Chang Jang-Yang, Shen Meng-Ru

Abstract excerpt

Purpose: Targeting tumor-associated macrophages with colony-stimulating factor 1 receptor (CSF-1R) inhibition reveals a strategy for cancer therapy. Here, we studied the impact of CSF1R germline genetic variant on CSF-1R signaling and the susceptibility to CSF-1R inhibitors.Experimental designs:CSF1R germline genetic variants were studied in 140 cancer patients. CSF-1R phosphorylation, endocytosis, and macrophage...

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PMID: 28724665
DOI: 10.1158/1078-0432.CCR-17-1007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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