Article

Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

2025-07-29

Abstract excerpt

Half of advanced melanoma patients fail to benefit from immune checkpoint blockade and novel treatments are urgently required. Testing topical medications used in other skin diseases for anti-cancer activity in an immunotherapy-resistant murine melanoma model, we counterintuitively found that glucocorticoids elicit rapid cytotoxic T lymphocyte (CTL)-dependent tumor control. Genetic ablation of the glucocorticoid r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35d8d4d3-e10c-5044-8eb9-63be0451b1b4
DOI: 10.1101/2025.07.24.666619

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axisDOI 10.1101/2025.07.24.666619Read

Glucocorticoid receptor inhibition enables tumor-infiltrating macrophages to overcome immunotherapy resistance in advanced melanomaSemantic proximity Read

Glucocorticoid receptor activation reprograms NK cells to drive AREG-mediated immunosuppression in skin cancerSemantic proximity Read

An endogenous glucocorticoid-cytokine signaling circuit promotes CD8 <sup>+</sup> T cell dysfunction in the tumor microenvironmentSemantic proximity Read

Glucocorticoid receptor controls atopic dermatitis inflammation via functional interactions with P63 and autocrine signaling in epidermal keratinocytesSemantic proximity Read

Glucocorticoid receptors, epidermal homeostasis and hair follicle differentiationSemantic proximity Read

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesisSemantic proximity Read

REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoidsSemantic proximity Read

Cutaneous inflammation accelerates the premalignant expansion of melanocytes bearing oncogenic mutationsSemantic proximity Read

Glucocorticoids delay RAF-induced senescence promoted by EGR1Semantic proximity Read

USP22 deficiency in melanoma mediates resistance to T cells through IFNγ-JAK1-STAT1 signal axisSemantic proximity Read

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expressionSemantic proximity Read

Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signalingSemantic proximity Read