Article

Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs

2021-05-03

Abstract excerpt

Optimizing drug candidates for blood-brain barrier (BBB) penetration in humans remains one of the key challenges and many devastating brain diseases including neurodegenerative diseases still do not have adequate treatments. So far, it has been difficult to establish state-of-the-art human stem cell derived in vitro models that mimic physiological barrier properties including a 3D microvasculature in a format tha...

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Literature Corpus work: 9a77b394-6c83-545e-bcc5-07c503cd3ce6
DOI: 10.1101/2021.05.03.442133

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